業績 Works
主要論文 Featured Papers
- すべての論文: Google Scholar
Probing nanomechanics by direct indentation using Nanoendoscopy-AFM reveals the nuclear elasticity transition in cancer cells, bioRxiv, Dec 2024
Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture, PNAS Nexus, Nov 2024 [PR page]
Crosstalk between mitotic reassembly and repair of the nuclear envelope, Nucleus, May 2024
ラミノパチーにおける核膜の修復異常, 生化学, Feb 2024
Epigenetic plasticity safeguards heterochromatin configuration in mammals, Nucleic Acids Research, Jul 2023
Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS, Journal of Cell Biology, Oct 2022 [PR page]
Superfluid helium nanoscope insert with millimeter working range, Review of Scientific Instruments, Oct 2022
RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells, Genes to Cells, May 2021
Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins, Journal of Cell Biology, Feb 2021 [PR page]
Variable immersion microscopy with a high numerical aperture, Optics Letters, Feb 2021
Adaptive multiorientation resolution analysis of complex filamentous network images, Bioinformatics, Jul 2020
A mosaic of old and young nucleoporins, Journal of Cell Biology, Jan 2019
The molecular architecture of lamins in somatic cells, Nature, Mar 2017
Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy, Journal of Cell Science, Jul 2016
Analyses of the Dynamic Properties of Nuclear Lamins by Fluorescence Recovery After Photobleaching (FRAP) and Fluorescence Correlation Spectroscopy (FCS), The Nuclear Envelope, May 2016
Autophagy mediates degradation of nuclear lamina, Nature, Nov 2015
Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy, Molecular Biology of the Cell, Aug 2015
Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells, Nucleus, Mar 2015
TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends, Nature Communications, Nov 2014
Interphase phosphorylation of lamin A, Journal of Cell Science, Apr 2014
Concentration-dependent lamin assembly and its roles in the localization of other nuclear proteins, Molecular Biology of the Cell, Apr 2014
Nuclear Lamins and Oxidative Stress in Cell Proliferation and Longevity, Cancer Biology and the Nuclear Envelope, Feb 2014
Meeting report: mitosis and nuclear structure, Journal of Cell Science, Nov 2013
Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors, Nucleus, Mar 2013
Mechanical model of blebbing in nuclear lamin meshworks, PNAS, Feb 2013
Chromosomal regions associated with prostate cancer risk localize to lamin B‐deficient microdomains and exhibit reduced gene transcription, The Journal of Pathology, Jan 2012
The functions of the nuclear envelope in mediating the molecular crosstalk between the nucleus and the cytoplasm, Current Opinion in Cell Biology, Feb 2012
The role of nuclear lamin B1 in cell proliferation and senescence, Genes & Development, Dec 2011
Simian virus 40 induces lamin A/C fluctuations and nuclear envelope deformation during cell entry, Nucleus, Jul 2011
Nuclear Lamins in Cell Regulation and Disease, Cold Spring Harbor Symposia on Quantitative Biology, Apr 2011
Nuclear Lamins, Cold Spring Harbor Perspectives in Biology, Sep 2010
The nucleoporin Nup153 affects spindle checkpoint activity due to an association with Mad1, Nucleus, Jan 2010
A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization, PNAS, Dec 2009
The A- and B-type nuclear lamin networks: Microdomains involved in chromatin organization and transcription, Genes & Development, Jan 2009
Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly, Journal of Cell Science, Aug 2008
The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication, Journal of Cell Biology, Apr 2008
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin, Genes & Development, Apr 2008
Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging, PNAS, Mar 2007
Dynamic interaction between BAF and emerin revealed by FRAP, FLIP, and FRET analyses in living HeLa cells, Journal of Structural Biology, Aug 2004
Heat-shock induced nuclear retention and recycling inhibition of importin α, Genes to Cells, May 2004
Multispectral imaging fluorescence microscopy for living cells, Journal of Structural Biology, Dec 2002
Spectral imaging fluorescence microscopy, Genes to Cells, Sep 2002
おまけ Extras
受賞歴・奨学金など Awords/Scholarship
川瀬雅貴 Masaki Kawase
第96回Best Papers (BP)賞 [受賞者の研究内容PDF] Best Papers Award 2024
細胞核の力学的特性はヘテロクロマチン構造によって強化される
日本遺伝学会 The Genetics Society of Japan
Nov 2024河野洋平 Yohei Kono
若手優秀発表賞 Young Scientist Award for Presentation 2022
核質のラミンCによる迅速な核膜修復機構の解明
Nucleoplasmic Lamin C Rapidly Accumulates at Sites of Nuclear Envelope Rupture
日本細胞生物学会 Japan Society for Cell Biology
Jun 2022河野洋平 Yohei Kono
基礎研究機構専門基礎研究塾細胞科学分野(大隅塾)
Specialized Academy for Cell Science (Ohsumi-juku) of Tokyo Tech OFR
塾生 Scholarship
Apr 2020 - Mar 2023
研究費・研究助成 Grants/Funding
Takeshi Shimi, Keisuke Miyazawa, Cong Quang Vu
Improvement of Genomic DNA Isolation Method by Nanoendoscopy-AFM
WPI-NanoLSI Transdisciplinary Research Promotion Grant (TDRP-G)
Funder: WPI-Nano Life Science Institute
Jun 2025 - Feb 2026 (G2506)Alexis Borowiak, Takeshi Shimi
WPI-NanoLSI Transdisciplinary Research Promotion Grant (TDRP-G)
Funder: WPI-Nano Life Science Institute
Jun 2025 - Feb 2026 (G2507)胡桃坂仁志, 藤芳暁, 山口潤一郎, 志見剛
核内環境による生命力維持機構の解明
Unraveling the mechanisms of vital force sustenance regulated by the nuclear environment
戦略的な研究開発の推進 戦略的創造研究推進事業
CREST Strategic Basic Research Programs, Core Research for Evolutional Science and Technology (CREST)
科学技術振興機構, Funder: Japan Science and Technology Agency (JST)
Oct 2024 - Mar 2030 (JPMJCR24T3)Takeshi Shimi, Keisuke Miyazawa, Cong Quang Vu
Development of Genomic DNA Manipulation Method Using Nanoendoscopy-AFM
WPI-NanoLSI Transdisciplinary Research Promotion Grant (TDRP-G)
Funder: WPI-Nano Life Science Institute
Jun 2024 - Feb 2025 (G2409)Alexis Borowiak, Takeshi Shimi
Investigating the nucleus elasticity of the beating cardiomyocytes nucleus in laminopathy by nanoendoscopy-AFM
WPI-NanoLSI Transdisciplinary Research Promotion Grant (TDRP-G)
Funder: WPI-Nano Life Science Institute
Jun 2024 - Feb 2025 (G2416)志見剛
核ラミナとヘテロクロマチンの構造が相互依存する分子メカニズムの解明
Elucidation of molecular mechanisms for the relationship of mutual dependence between the nuclear lamina and heterochromatin
科学研究費助成事業, 基盤研究(C)
Grant-in-Aid for Scientific Research (C)
日本学術振興会, Funder: Japan Society for the Promotion of Science (JSPS)
Apr 2024 - Mar 2027 (JP24K09434)藤芳暁, 工藤史貴, 志見剛
細胞核形成における分子機構についての研究
科学研究費助成事業, 基盤研究(B)
Grant-in-Aid for Scientific Research (B)
日本学術振興会, Funder: Japan Society for the Promotion of Science (JSPS)
Apr 2021 - Mar 2024 (JP21H01876), Apr 2024 - Mar 2025 (JP23K21093)志見剛, 河野洋平, 木村宏
細胞シート工学を用いたラミノパチー疾患モデル構築と核ラミナ修復機構の解明
Mechanobiological study of nuclear rupture in laminopathies by cell sheet engineering
科学研究費助成事業, 国際共同研究加速基金(国際共同研究強化(B))
Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
日本学術振興会, Funder: Japan Society for the Promotion of Science (JSPS)
Oct 2020 - Mar 2025 (JP20KK0158)志見剛
核ラミナが核膜孔複合体の構築を制御する分子メカニズムの解明
Elucidation of molecular mechanisms for reassembling the nuclear lamina and NPCs
科学研究費助成事業, 基盤研究(C)
Grant-in-Aid for Scientific Research (C)
日本学術振興会, Funder: Japan Society for the Promotion of Science (JSPS)
Apr 2020 - Mar 2023 (JP20K06617)志見剛
核ラミナが核膜孔の分布を制御する分子メカニズムの解明
Structural study of the association between the nuclear lamina and nuclear pore complexes
科学研究費助成事業, 研究活動スタート支援
Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up
日本学術振興会, Funder: Japan Society for the Promotion of Science (JSPS)
Apr 2019 - Mar 2021 (JP19K21178)
学会・研究会 Academic Society
- 日本分子生物学会 The Molecular Biology Society of Japan
- 日本細胞生物学会 Japan Society for Cell Biology
- 日本生化学会 The Japanese Biochemical Society
- 日本生理学会 The Physiological Society of Japan
- 日本再生医療学会（河野） The Japanese Society for Regenerative Medicine
- 日本遺伝学会（川瀬） The Genetics Society of Japan
- 染色体ワークショップ・核ダイナミクス研究会 The Chromosome Workshop and the Nuclear Dynamics Meeting
- 日本エピジェネティクス研究会（川瀬） The Japanese Society for Epigenetics